Pregnenolone and Rheumatoid Arthritis
One of the many benefits attributed to pregnenolone is its ability to help patients suffering from rheumatoid arthritis; however, there is not sufficient evidence to support this claim.
A study conducted in 1949 showed that only 1 out of 10 patients showed “marked improvement.” In the same study, another one of the patients showed moderate improvement while three showed “a very doubtful improvement.”
A follow-up study conducted in 1951 showed similar results. Out of the four patients observed, only one showed “marked clinical improvement;” another showed “a very minor clinical improvement;” and the other two “showed no improvement whatsoever.”
The researchers concluded that, while pregnenolone is found to be useful in helping with other conditions, “the results do not support the belief that pregnenolone exercises any beneficial action in rheumatoid arthritis.”