Lipoic Acid differences
Q: What is the difference between Alpha Lipoic Acid pure powder, R-lipoic Acid and R+Lipoic Acid?
A: Lipoic Acid Chemical Forms: the R and S Isomers
Alpha-Lipoic Acid (or thioctic acid) is synthesized from the amino acid Cysteine and Octanoic acid in plants and animals as both the R and S isomer with a great majority as R-Lipoic Acid and only trace amounts of S-Lipoic Acid. When Alpha-Lipoic Acid is synthesized in a laboratory, a 50/50 racemic mixture of the R and S enantiomers results in what we call R/S Lipoic Acid, which is the most popular form of commercially available Lipoic Acid (also named RAS Lipoic Acid or All Racemic Lipoic Acid). New technological advancements have allowed for the stabilization and isolation of the RLA (R-Lipoic Acid isomer), which is believed to account for all the benefits seen from studies with R/S Lipoic Acid. Supplementing with pure RLA, thus eliminating the presence of SLA (S-Lipoic Acid isomer), creates new opportunities for intensive nutritional support because SLA is believed to interfere with the effectiveness of RLA.
How is Stabilized R-Lipoic Acid Different From Other R-Lipoic Products on the Market?
R-Lipoic Acid is a highly unstable compound that easily polymerizes into a sticky rubber or glue-like substance if it is not prepared, stored and processed correctly. This may adversely affect bioavailability. Stable RLA is a non-hygroscopic, non-polymeric potassium salt form of RLA. The capsules are heat stable, characterized by fast dissolution rates, high solubility and absorption. They are also free of residual solvents and moisture.
There are wide variations in the R/S ratios and total polymer contents of raw material and finished products now on the market. Few supplement companies have experience with RLA and are unaware of the myriad of problems associated with its encapsulation and stability. Designs for Health’s Stabilized RLipoic Acid is the only stable and highly bioavailable form of R-Lipoic Acid available on the market.
Compared to SLA, RLA causes 50% higher peak plasma levels of lipoic acid and 60-85% higher total absorption. Feeding lipoic acid to animals at risk of cataract caused a 2-7 fold higher uptake of RLA versus SLA in the lens content of lipoic acid, and reduced the development of experimentally produced cataract by 50%. Alpha R-Lipoic acid has been reported to be 10 times more powerful than standard Alpha RSLipoic Acid!
The dosage this in this is R-Lipoic Acid Supreme (Stabilized) by DFH is 100 mg per capsule. If you & your husband need the amount you take to be the specified levels you listed, you could take 4-6 capsules of this, plus this which comes in a 50mg capsule: Alpha R-Lipoic Acid by BioGenesis to achieve what has been recommended for you to take.